Abstract
Five hundreds and ninety-two patients with squamous cell carcinoma of the maxillary sinus were treated by radiation therapy alone (136 patients) or in combination with chemotherapy (456 patients), at the Department of Radiology, Osaka Uuniversity Hospital between 1967 and 1984. After a median follow-up of 12 years (range 6-24), actuarial 5-year and 10-year survival rates were 34% and 24%, respectively. The 5-year and 10-year survival rates according to T stage were as follows: T2 (n=107 patients): 51% and 37%, T3 (n=318): 37% and 27%, and T4 (n=158): 22% and 18%, respectively. The mean dose (TDF) of radiation was 123 (range 59-184) for radiotherapy alone (RT) group, and 92 (range 49-141) for radiotherapy combined with intraarterial infusion of 5-fluorouracil (RT+FU) group. Recurrence-free and actuarial survival rates at 5-years were 11% and 20% for RT group, and 42% and 57% for RT+FU group, respectively.
It was concluded that radiation therapy (50Gy/25f/35d) combined with 5-FU (2.5gr/10f/35d) is an acceptable treatment strategy for maxillarr sinus carcinoma: it yielded a high rate of disease control and functional eye and maxilla preservation.
