Abstract
G-CSF is applied to various fields in cancer chemotholopy. Myeloid leukemia cells have often G-CSF receptor.
Administration of G-CSF to myeloid leukemia needs carful observation.
For infection in patients with hematological diseases non responders to 3 day antibiotic therapy were randomized to two groups of antibiotic therapy with or without G-CSF. Significant difference in the response rate was obtained. In bone marrow transplantation G-CSF treated group showed significantly shorther granulocyte recovery. After 5 year follow up the group showed also significantly lower incidence of chronic GVHD. This data is now reexamined in the international cooperative study of Asian Pacific BMT study group.
