Abstract
Various cytokines have been investigated to test the effect on thrombocytopenia. Interleukin-3 has escalated nadirs of thrombocytopenia induced by chemotherapy and promoted recovery of thrombocytopenia. Major toxicities occured were fever, flu-like symptomes, headache and othtrs but these were relatively mild.
Interleukin-6 has shown effect on thrombocytopenia induced by chemotherapy but toxicities such as fever, fatigue and others were relatively severe.
Interleukin-11 has shown thrombostimulatory effects in phase I trial and phase II trials are in progress.
Thrombopoietin has demonstrated stimulatory effects on production and maturation of megakangocyte and has promoted recovery of thrombocytopenia induced by chemotherapy and radiotherapy. Phase I trials are in progress in western countries.
