Abstract
Purpose: Usually, the middle-aged patients with non-Hodgkin's lymphoma and concomitant other adult diseases can not be tolerable for intensive chemotherapy. Then we introduced a new regimen composed of radiation for local and sorrounding lymph node areas, and brief reduced-dose chemotherapy into treatment for such patients.
Subjects and Methods: Thirth-eight patients with Stage IE or Stage IIE non-Hodgkin's lymphoma of the Waldeyer's ring were a core of this study. Histopathologically they were diagnosed as diffuse intermediate grade. In addi-tion, they suffered from other adult diseases such as cardiovascular diseases, cereblovascular disorders, diabetus melitus, chronic liver diseases, etc. They were treated by the combined modality composed of reduced-dose chemo-therapy (70%-ACOP: 2 cycles or 70%-MACOP-B: 8 weeks) and regional lymph node irradiation (30Gy) puls boost irradiation (10Gy) to inolved area (total 40Gy).
Results: No relapses were observed in the radiation field, the 5-year disease-free survival rate and cause-specific survival rate for all patients were 85.7% and 91.4%, respectively. There were no differences of the 5-year disease-free survival rate between stage IE and IIE, among the pathological subtypes, among the complications and etc.
Conclusion: The regimen composed of regional lymph node irradiation (30Gy) puls boost irradiation (10Gy) to involved area (total 40Gy) and reduced-dose chemotherapy (70%-dose ACOP, 70%-dose MACOP-B) is a safe and useful approach to treatment for diffuse intermediate grade of B cell lymphoma in middle-aged patients having other adult diseases.
