Abstract
The systemic and local side effects of superselective intraarterial infusion of cisplatin (CDDP) for head and neck cancer were investigated. Sixty patients with head and neck cancer were treated with this therapy at Fukushima Medical University between November 1998 and April 2001. The catheter was inserted under fluoroscopic guidance via the right femoral artery in 58 patients and superficial temporal artery in 8 patients. Dose of CDDP of 80-100mg/m2 were infused weekly. After completion of CDDP infusion, Sodium thiosulfate was administered by drip phleboclysis, and steroid was administered through the catheter.
As systemic side effects more severe than grade2. anorexia was the most common (27/60). Leucopenia was the second most common (17/60), nausea and vomiting were the third most common (12/60), and other side effects were decrease of creatinine crealance (4/60), anemia (4/60), and thrombocytopenia (3/60). Local side dffects were seen in ten cases: postoperative sequestum of maxilla (3), postoperative diastasis (2), facial nerve palsy (1), partial necrosis of tongue caused to the fatal complication (1), suspected infarction of CNS (2), and alopecia (1).
