Possibility of migraine prevention by propranolol treatment during premonitory symptoms

Abstract

　The effect of 10 mg propranolol during premonitory symptoms was assessed in 56 patients (43 without aura and 13 with aura）. Propranolol successfully prevented migraine attack at least some of the time in 54 (96%） patients, with 29 (52%） patients reporting > 50% prevention frequency. Further, pain alleviation was reported by 44 (79%） patients. Prophylactic treatment may be highly desirable for cases in which daily life is adversely affected despite acute treatment. It is critical to select a therapeutic strategy suitable for the frequency and time course of migraine attacks, such as conventional daily prophylactic treatment, preventive treatment during premonitory symptoms, or a combination of the two treatments as applicable.