Can COVID-19 vaccination induce cluster headaches?
2023 Volume 49 Issue 3 Pages 604-607
Details
2023 Volume 49 Issue 3 Pages 604-607
Headache is a relatively common adverse reaction after vaccination against the novel coronavirus disease (COVID-19) , but cluster headache rarely occurs. We experienced a patient with episodic cluster headache who had been attack-free for 10 years. However, on the day following the third dose of COVID-19 vaccine (mRNA-1273, Moderna) , his cluster headache relapsed. In this case, we considered the possibility that COVID-19 vaccination induced inflammation of the fluctuating trigeminovascular system. Based on our findings and those of other reported cases, we describe a hypothesis regarding the mechanism by which COVID-19 vaccines induce cluster headache as well as the relevant pathogenesis of cluster headache.
