Elucidation of a mechanism of therapeutic effect on atopic dermatitis by Toyotomi hot spring bathing

Abstract

[Background]

Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disorder and it is difficult to completely cure. Recently, the therapeutic effect on atopic dermatitis by Toyotomi hot spring bathing has been reported. Therefore, the current study aimed to elucidate a mechanism of the effect.

[Methods]

In this study, a mouse model of atopic dermatitis was used. The therapeutic effect on atopic dermatitis of Toyotomi hot spring bathing and/or applying the oil that derived from Toyotomi hot spring was evaluated by comparing of severity scoring of atopic dermatitis (SCORAD).

[Results]

The value of SCORAD was tended to decrease in oil applying group as compared with the control group.

[Consideration]

The results in this study suggested some compound that has the therapeutic effect on atopic dermatitis is included in the oil derived from Toyotomi hot spring.