Abstract
Objective–The purpose of this study was to investigate the histopathological changes of the matrix components of cartilage in the articular condyle after removal of the side shift plate. The expressions of type X collagen and vascular endothelial growth factor (VEGF) were studied histopathological and immunohistochemically.
Design–Side shift plates were attached to the anterior teeth in the maxilla of 6-week-old male rats for mandibular displacement. The plates were worn for 8 weeks. Observations were made at 0, 1, 2, 4 and 8 weeks after removal of the side shift plate.
Results–In histopathological findings, the timing of proliferation of the layer of hypertrophy varied between the bilateral sides. In immunohistochemical findings, a significant elevation in the expression of type X collagen in the displacement side was observed at 1 week after removal of the side shift plate.
Moreover, the expressions of VEGF were elevated in both sides (displacement and non-displacement side) at 0-1 weeks after removal of the side shift plate. At 4 weeks after removal of the side shift plate, the significant elevation in expressions of type X collagen and VEGF was reduced in the displacement side.
Conclusions–It is suggested that the cartilage of the condyle is restored by the increase in type X collagen and VEGF by early removal of the causes during growth.
