Treatment of Mandibular Prognathism in a Patient with Pituitary Gigantism-A Case Report

Abstract

Pituitary gigantism is a rare disease that results from chronic exposure to GH (Growth Hormone). The syndrome is characterized by excessive height and growth of several tissues, including bony and soft tissues. Mandibular prognathism is often seen in the patient with pituitary gigantism. A case of pituitary gigantism accompanied by prognathism is reported here. The patient had a pituitary adenoma that caused hypersecretion of GH. Surgical resection of the pituitary adenoma, by a transsphenoidal approach, reduced the serum level of GH and Sm-C (Somatomedin-C). Preoperative orthodontic treatment started after the serum level of GH was stable and normal. Orthognathic surgery by SSRO (sagittal split ramus osteotomy) and Le Fort I osteotomy was performed, and good and satisfactory occlusion was obtained.