Abstract
Fibrinogen that is the first factor of thrombokinesis, is one of the most impotant factor among blood coagulation factors, and exist as matrix that relates to both blood coagulation and fibrinolytic system. Hypofibrinogenemia will occur when fibrinogen in the blood plasma reduces. However, this disease is uncommon.
In this paper, we report the experience of tooth extraction of patient with hypofibrinogenemia.
A 72-year-old woman visited our department on April 14th 1988, complaining of pain in occlusion at 26, 27. There is no hemorrhagiparono in her blood relation except for the patient. She had valvular disease of the heart, stenocardia, gastric ulcer, and hypertention in her history. She had been diagnosed as hypofibrinogemia in preoperative examination of gastric ulcer. Under diagnosing as 26, 27 chronic ostitis alveolaris, she admitted to our University Hospital on May 23th 1988, and then she was intended to transfuse fresh frozen plasma, originate in human blood pre and post operation and extract 26, 27.
Quantity of fibrinogen of preoperation was 39mg/dl, and so 5-units of fresh frozen plasma were transfused as aim of 60mg/dl and then it rose to 74mg/dl Result of examination about hemorrhagic diatheses improve, as usual way 26, 27 extract after extraction condensation of oxidized cellulose and sew up a wound, and then we used protective device, and we could get a good condition of stopping of bleeding. But out of consideration of fresh frozen plasma at 28 hours after operation quantity of fibrinogen was 42mg/dl and she get well without bleeding.
