Abstract
Employing cylinder-plate assay system, studies were undertaken to examine inhibitory effects of various sera against Candida albicans and Trichophyton mentagrophytes. Human serum and immunized rabbit serum showed inhibitory effects against C. albicans, but normal rabbit serum did not. All these three sera showed inhibitory effects against T. mentagrophytes. These activities were abolished by the addition of iron.
Transferrin which was partially purified from immunized rabbit serum did not show any inhibitory effects. However, when the stimulation factor, which was also purified from immunized rabbit serum, was added to the transferrin, the activities were restored. It was found that the activites were correlated with unsaturated iron binding capacity (UIBC).
