Studies on the Antifungal Activities of Sulconazole Nitrate I. In Vitro Antifungal Activities

Abstract

Of a series of studies on the antifungal activities of sulconazole nitrate, a newly developed imizdazole antimycotic, this paper describes its in vitro antifungal activities against a variety of pathogenic fungi. The minimum inhibitory concentrations of the drug were determined by means of agar dilution method in comparison with econazole nitrate, using Sabouraud dextrose agar plates. As a result, sulconazole nitrate was found to exhibit a potent inhibitory effect with a broad spectrum, particularly against Cryptococcus neoformans, dermatophytes, dematiaceous fungi and dimorphic fungi.