Abstract
Following the previous report on in vitro antifungal activities of sulconazole nitrate, a novel imidazole antimycotic, it was reconfirmed that this compound posessed a broad antifungal spectrum with more potent fungistasis against filamentous fungi including dermatophytes and dimorphic fungi than against yeast-like fungi including Candida albicans and C. pseudotropicalis, and that Cryptococcus neoformans, in particular, was extremely sensitive to this drug.
This in vitro antifungal activity of sulconazole nitrate was not much affected by changes of inoculum size or pH of the medium and by the addition of human blood. This activity was exhibited more potently on Sabouraud dextrose agar plates than in Sabouraud dextrose broth.
The fungistatic activity of sulconazole nitrate was almost the same as that of clotrimazole in terms of MIC values against a variety of pathogenic fungi except Cr. neoformans against which the former was found to be more effective than the latter.
The growing cells of C. albicans and C. pseudotropicalis were more sensitive to the killing effect of this drug than the resting cells.
