Abstract
A 54-year-old man with fungal keratitis which did not respond to oral ketoconazole was successfully treated with intravenously infused miconazole, a synthetic imidazole derivative. In this case, healing and regression of the corneal ulcer began on the fourth day after the initiation of miconazole monotherapy (from 400mg to 1, 200mg per day). The clinical evidence of corneal infection disappeared completely after three weeks and visual acuity improved from 0.05 to 0.7. Aside from a slight increase in serum triglycerides and β-liporoteins, the drug appears to be well tolerated.
