Abstract
The efficacy of FK-936, PY(1)+CTZ(2), -an external liquid preparation-was evaluated in guinea pigs with Trichophyton spp. infection and the following results were obtained:
1) FK-936 was significantly superior to CTZ and PY preparations in therapeutic activity against experimentally induced infection with T. mentagrophytes Junten. The mean negative rates of the culture specimens treated with FK-936, CTZ and PY preparations were 85, 76 and 61%, respectively.
2) The efficacy of FK-936 on experimental infection with clinically isolated T. rubrum No. 68 was also significantly superior to that of CTZ and PY preparations. The mean negative rates of the culture specimens treated with of FK-936, CTZ and PY preparations were 90, 69 and 60%, respectively.
3) The excellent efficacy of FK-936 against experimental Trichophytosis was confirmed by the MIC and fungicidal activity in vitro.
