A Clinical Study on Deep Mycosis Complicated by Leukemia

Abstract

We investigated ten leukemia patients complicated by deep mycosis from 1985 to 1988. Aspergillosis and Candidiasis are recognized in each five cases. Seven are systemit and three are localized. In our results, the following two clinical states can be considered as factors for the involvement of deep mycosis.
First, almost every case recorded the same duration of leukopenia under 3, 000/μl and febrile over 38.0°C. Second, minimum WBC count was 100-400/μl in nine cases. The diagnosis of mycosis by culture had done just before the dead. Abnormal shadow on chest X-P were involved in seven patients and the duration between pneumonia and the dead were from ten to twenty days. Although they received myconazole or amphotericin B (per os) for long time, administration of intravenous amphotericin B was started just before dead. Autopsy revealed that all ten cases had lung mycosis with spleen, liver and kidney invasion. These results suggest that abdominal CT and echo examination are important for detected mycosis.