Abstract
In vitro and in vivo anti-Candida albicans activities of butenafine hydrochloride (KP-363) were studied. The in vitro activity against C. albicans in Sabouraud dextrose broth was markedly influenced by the pH value of the medium. The greatest activity of the drug was achieved at pH 5.0. Under this test condition, the geometric mean MIC of KP-363 against 57 clinical isolates of C. albicans was 27 μg/ml, while it was only slightly active in the pH-unadjusted medium (pH 5.9).
The therapeutic effect of KP-363 on experimental cutaneous candidosis in guinea pigs was almost equal to that of bifonazole, although it was inferior to that of miconazole.
