Abstract
The involvement of cell wall glucans in the process of dimorphism in Paracoccidioides brasiliensis has been proposed for many years. The control of glucan synthetase activity through cytoplasmic factors is also considered. Current research on biochemical aspects of dimorphism in P. brasiliensis suggests that proteinases are involved in the control of β-glucan synthetase activity in the generation of the fungal cell wall. The probable involvement of protein disulfide reductase is also suggested. A complementary model of yeast mycelium transformation is proposed.
