Interferon-γ Production by Exposure to Trichophytin of Peripheral Blood Mononuclear Cells from Patient with Acute Dermatophyte Infection

Abstract

Interferon-γ was present in the culture supernatant of peripheral blood mononuclear cells (PBMC) obtained from a patient who had acute infection with Trichophyton rubrum following 72 hours of incubation with trichophytin. The blood mononuclear cells were also strongly stimulated by trichophytin. These findings indicate that a patient with acute dermatophyte infection has peripheral T-lymphocytes that produce IFN-γ, which are known to play an important role in the development of delayed type hypersensitivity reaction in the skin.