Abstract
The antifungal agent, ZM-589 is a topical solution containing 2% Tolnaftate (TN) and 10% Salicylic acid (SA) as active ingredients.
The minimum inhibitory concentrations (MICs) for TN, SA and their combination were determined here using ten strains among five species of dermatophytes. The therapeutic effect of ZM-589on experimental cutaneousTrichophyton mentagrophytesinfection in guinea pigs was compared with ZM-SA (ZM-589 without SA), ZM-TN (ZM-589 without TN) and three commercial products: 1% Miconazol nitrate solution, 1%Ciclopirox olamine solution and 5% Exalamide solution (containing 2% Salicylic acid).
MICs of TN and SA were 0.06-0.2 and around 1250μg/ml, respectively. MIC of the combination of TN and SA was essentially the same as that of TN alone.
In a comparative study on experimental dermatophytosis on guinea pig skin, ZM-589 was statistically superior to any preparation used in the study including ZM-SA. The results were also supported by data on the negative rate of culture.
These results suggest that ZM-589 can be beneficial in the clinical treatment of patients with dermatophytosis.
