Protective Activity Induced by Oral Administration of Amphotericin B against Infections due toCandida albicans and Vaccinia Virus in Mice

Abstract

Orally administered amphotericin B (AmB) induced protective activity against infections due to vaccinia virus and Candida albicans in mice. This activity was also confirmed in immunocompromised mice. Analyses of the kinetics of peripheral blood cells treated with oral AmB indicated an increased ratio of polymorphonuclear leukocytes (PMN). Enhancement of γ-interferon (IFN) production and of NK-cell activity was also observed. The data were considered to indicate that γ-IFN produced by oral AmB has an important part as one of the factors protecting mice against both candidiasis and vaccinia virus infection.