1996 Volume 37 Issue 4 Pages 229-233
Fungal infections following bone marrow transplantation remain a major cause of morbidity and mortality. We reviewed 149 autopsies with bone marrow transplantation (BMT) in UCLA Medical Center for the period 1985-1994, focussing on the deep fungal infection.
Deep fungal infections were demonstrated in 47 (31.5%) of 149 patients with BMT. Causative fungi, commonly demonstrated in patients with BMT, were Aspergillus species and Candida species, and disseminated disease was found in approximately one-fourth of patients infected.
Examination of the incidence of causative fungi showed that candidiasis has been markedly decreasing since 1992, while aspergillosis has been increasing. It is suggested that the therapeutic difficulty of aspergillosis might have raised the mortality and incidence of invasive aspergillosis.
