1996 Volume 37 Issue 4 Pages 245-249
The combined effects of lysozyme and an azole antifungal, lanoconazole were investigated by microbroth dilution method against Candida albicans in vitro; growth of 7 of 8 C. albicans strains tested was inhibited for 14hr by 100∼200μg/ml of eggwhite lysozyme. IC 50 of the eight Candida strains, which is the concentration of lanoconazole causing 50% inhibition of growth, was estimated to be lower in the presence of 100μg/ml of lysozyme than in its absence. Using a typical strain of C. albicans, TIMM 1768, this combination was shown to be synergistic by analysis of the combined antimicrobial activity and was observed in Candida culture for as long as 72hr. Roles of this combination effect in anti-Candida therapy by lanoconazole were discussed.
