Abstract
Recently not only neutrophils but also macrophages have been recognized to have important roles in the host defense mechanism against deep-seated infection of Candida albicans. Activated macrophages can kill Candida cells and inhibit their growth. Macrophages act as both effector cells against Candida albicans and regulator cells which enhance antiCandida activity of other effector cells such as neutrophils through cytokine production. Therefore, Immunological manipulation of the macrophage function seems to make it possible to augment the host defense mechanism against candidiasis. As a typical example, the therapeutic effects of a traditional medicine, Juzen-taiho-to against experimental fungal infection in mice and its mechanism are discussed.
