Free Breathing Multiple Post Labeling Delay Renal Perfusion Imaging [Presidential Award Proceedings]

Abstract

　Pseudocontinous arterial spin labeling (pCASL) renal perfusion imaging is typically restricted to a single post-label delay (PLD) time. While multiple PLD (mPLD) times can be achieved using sequential scans with different PLD times, this procedure is time consuming. A rapid acquisition method was developed using Hadamard encoding for mPLD pCASL imaging, combined with a motion robust timing and readout strategy to permit free-breathing renal ASL. The feasibility study explores the application of Hadamard encoding to renal perfusion imaging where spin labeling is affected by pulsatile flow, and demonstrated that a cardiac-triggered scan provided stable perfusion images achieving arterial transit time-corrected renal blood flow with seven PLD acquisitions.