Development of Hyperpolarized MR Imaging for Clinical Application

Abstract

　Physiological functions such as energy metabolism and free radicals are responsible for maintaining homeostasis of living bodies and play an important role in various diseases and treatments. Therefore, these functions can be used as imaging biomarkers for new disease imaging. Dynamic nuclear polarization (DNP)-MRI is a powerful technique that can be used to obtain the spatio-temporal information of glucose and tissue redox metabolism processes. In this article, we also introduce our study of glucose and in vivo redox metabolic imaging as well as possibilities for clinical application.