A case of drug-induced kidney injury developed after the administration of oral vancomycin improved by pharmaceutical intervention

Abstract

Recently, drug-induced kidney injury (DKI) has been increasing with society’s aging. Therefore, the early detection and severity prevention of DKI by pharmacists is expected. We experienced a case of DKI develop after oral vancomycin (VCM) treatment. The renal function of the 80-year-old man rapidly declined after receiving VCM and intravenous teicoplanin (TEIC) treatment for pneumonia and colitis caused by methicillin-resistant Staphylococcus aureus. VCM-induced acute interstitial nephritis was suspected because the patient’s renal function further declined in spite of the discontinuation of TEIC. The patient’s renal function was improved by steroid therapy and discontinuation of VCM. Regarding the pharmaceutical intervention against DKI suspecting acute interstitial nephritis, it is essential to discontinue the suspected drugs and collaborate with a doctor, such as considering the early introduction of steroid therapy.