Orofacial Granulomatosis: Report of Two Cases

Abstract

We report two cases of orofacial granulomatosis in the oral region. Case 1: The patient was a 59-year-old woman who complained of swelling and redness of the gingiva. Biopsy specimens showed a non-caseating granulomatous inflammation. Blood analysis and chest radiograph showed no evidence of Crohn's disease or sarcoidosis. After treatment with oral prednisolone therapy, gingival symptoms clearly improved. Case 2: The patient was a 41-year-old man who had been followed by his physician for suspicion of sarcoidosis. He presented with a nodular lesion in the buccal mucosa. Pathology of the resected specimen showed a non-caseating epithelioid granuloma. Systemic and biochemical examination ruled out Crohn's disease and sarcoidosis. The final diagnosis of these two patients was orofacial granulomatosis.