Evaluation of Clinical Efficacy of Cepharanthin^® (gargle-internal use) Treatment for Oral Mucosal Lesions

Abstract

Patients with 43 oral mucosal lesions were treated by Cepharanthin^® with gargle-internal use (gargle group) or internal use (internal group), and the clinical effects of the two methods were compared. The dose of Cepharanthin^® was 15mg per day for 2 weeks. The efficacy was classified as excellent, moderate, or poor. In consideration of the incidence of side effects, the usefulness of the two treatments was investigated. In the gargle group, the rate of excellent or moderate efficacy was 83.4% for glossodynia, 100% for aphthous stomatitis, 25.0% for reducing the size of lichen planus, and 75.0% for relieving the pain of lichen planus. Side effects were not observed in the internal group, but in the gargle group, they were observed in five of 32 cases (15.6%). The usefulness of the two treatments significantly differed for stomatitis, but not for glossodynia or lichen planus.