Abstract
The efficacy of Cevimeline hydrochloride hydrate application in Sjögren's syndrome (SS) patients with dry mouth, was evaluated. A total of 51 patients with dry mouth from SS:2 males and 49 females, of mean age 65.8 years (34-84), took this drug during September 2001 to May 2002, for a mean treatment period of 22.7 weeks (6-37). Fifteen and 36 patients were respectively given doses of 90mg/day and 60mg/day of this drug. The mean sialometric incrcase was 117.2%, and 59.5% of the patients had “improved” sialometric observation. “Improved” and “better” subjective symptoms were achieved in 64.8% of patients, while 81.8% response rate of objective symptoms. Overall efficacy of this treatment was 75.7%, with adverse reactions occurring in 35.3% of patients.
