Abstract
The continual administration of Bleomycin (BLM), as has beem observed, can bring on fibroplastic alteration in mouse pulmonary tissue. In the enzyme-induced mouse by phenobarbital, on the other hand, rather increased activity and reduced pyrexia have been observed. Observations were done on the distribution of cortisol in the vital organs of mice in continual BLM-administration: the ones with preceding phenobarbital treatment and those without such treatment. Following are the results of the comparison between the data for the above-mentioned mice and the data for the control group.
1) The BLM-administrated mice had tissues alteration suggesting pulmonary fibroplastic phenomena.
2) Continuing high concentrations of cortisol in the tissues were observed in the BLMadministrated mice.
3) The aspects of the distributions of cortisol in the tissue of mice with preceding phenobarbital treatment were similar to the data for the control group.
These results suggest that fibrosis of the lung by BLM can be prevented by enzymeinduction.
