Localized amyloidosis of minor salivary gland in buccal mucosa

A case report and immunohistochemical study

Abstract

Pathological findings were reported in a 70-year-old female with localized amyloidosis in buccal mucosa. Clinically, she had no symptom of generalized amyloidosis. The buccal lesion consisted of amyloid deposition of minor salivary gland. The amyloid protein of this case was identified as protein AλE by potassium permanganate treatment and immunoperoxidase technique (PAP method). Although the mechanism of amyloid deposition in localized amyloidosis as in this case was not to clearly elucidated, it might be suspected that the amyloidogenic light chain of secretory-typed immunoglobulin was transformed into amyloid protein by some lysosomal enzymes.