Abstract
The analgesic effect and safety of a single dose of Indoprofen (IND) 200mg was compared with that of Aspirin (ASP) 750mg and Inactive placebo (PL) In a double blind trial in patients with postexodontic impacted wisdom teeth pain. The numbers of patients analyzed were 68 for the IND group, 65 for the ASP group and 81 for the PL group. The following results were obtained.
1. In pain improvement rating, moderate or better improvement was obtained in 52 patients (83.9%) of the IND group, 23 (41.8%) of the ASP group and 23 (29.9%) of the PL group. There was a significant superiority for IND over the other two agents (P<0.001).
2. The onset of analgesic effect of IND was 30 min., and efficacy was maintained for 6 hours. At all evaluation times, pain in the IND group was significantly less than in the other two groups (P<0.001 or P<0.01).
3. Side effects were observed in 5 patients (7.4%) of the IND group, 6 (9.2%) of the ASP group and 4 (4.9%) of the PL group with no significant difference.
4. Overall usefulness was rated as “markedly useful” in 24 patients (38.7%) of the IND group, 3 (5.5%) of the ASP group and 3 (3.9%) of the PL group. There was a significant difference among the three groups (P<0.001).
