Abstract
Combination chemotherapy was effectively used after the surgical operation of a case of 30-year-old female with osteosarcoma arising in a fibrous dysplasia of the left mandible. In this case, a high dose methotrexate (MTX 12g/“cours”) with citrovorum (CF) rescue was administered mainly by six “cours”, in combination with several chemotherapeutics, such as Adriamycin (50-70 mg), Endoxan (EX 800-1, 000 mg) Vincristine (VCR 2.5 mg), resulting in total dose of 72 g, 490 mg, 6, 900 mg and 19 mg, respectively. This therapy has probably been very effective, because a possibility of recurrence was strongly considered from the viewpoints of a relapse after the first operation and the clinical findings during the second surgery.
Side effects of the chemotherapy were relatively mild and temporary.
No relapse has been observed in the last two years after the treatment.
It was proved that this chemotherapy was applicable with safety and very effective for the treatment of osteosarcoma provided that the cases are chosen and put under supportive medical care.
In this paper, an administration method of such chemotherapeutics is described.
