Distribution of KBT-1585 in the oral tissue of mice

Abstract

Distribution of KBT-1585 was examined in oral tissue and inflamed mouth floor of mice by agar well method.
After oral administration of KBT-1585 200 μ g/g in mice, the tissue concentration of mandibular bone, tongue, masseter, submandibular gland, femur and serum reached a peak in 5 minutes and that of mouth floor in 15 minutes.
The tissues in order of concentration were the serum, tongue, mouth floor, masseter, mandibular bone, femur, submandibular gland.
After oral administration of KBT-1585 200 μ g/g in mice of which mouth floor had been inflamed, the concentration of inflamed mouth floor reached a peak in 15 minutes. Compared with normal mouth floors, KBT-1585 was distributed rather low in inflamed mouth floors, but the concentration maintenance was good.