The chemotactic factors on macrophage from the pus

Abstract

It is well known that macrophages play a key role at the healing phase of acute inflammation as scavengers through phagocytosis and digestion of tissue-degradated products. In order to perform this key role, macrophages must accumulate at inflammatory sites. Some chemotactic factors on macrophages were isolated and identified from inflammatory sites.
Since pus is often produced with acute bacterial infection, it is considered that macrophages accumulation at the disease sites is significant for repair We examined whether the macrophages chemotactic factors on existed in the pus.
The results revealed that there were several kinds of chemotactic factors in the pus according to partial decrease of chemotactic activity with dialysis or heat treatment at 56°C for 30min. It was also shown that the pus chemotactic activity was completely inhibited by trypsin treatment.