High-dose methotrexate citrovorum factor rescue and VEPA therapy as a post-operative adjuvant chemotherapy for the osteosarcoma of the mandible

Abstract

A rare lesion, osteosarcoma of the jaw with a good prognosis, from high dose therapy in the post operative period, is presented.
Male patient diagnosed as osteosarcoma of the mandible (right side) was treated with a high dose of methotrexate along with VEPA therapy as post-operative adjuvant chemotherapy. This combined therapy was significantly effective without any local recurrence or distant metastasis observed in the 2-years follow-up studies. A review of the past literature was discussed.