Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
The study of oral hemorrhagic management in patients with blood disease
The XIXth series the management of oral bleeding In two patients with congenital deficiencies of both factor V and VIII
Manabu TAKEUCHIMasafusa MATSUDAKeiichi KAWAIYasunori SUMIHideharu SUZUKIToshio KANEDA
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1987 Volume 33 Issue 4 Pages 760-763


Congenital deficiencies of both factor V and VIII represent a rare blood coagulation disorder. The hemorrhagic management of this disease has been performed by transfusion of fresh plasma and factor VIII concentrate by this time.
In this report, the administration of 1-deamino-8-D-arginine-vasopressin (DDAVP), which is effective for the bleeding in patients with mild and moderate hemophilia A and von Willebrand's disease, resulted in the hemostasis of oral bleeding in two patients with this disorder. Factor VIII coagulability (VIII: C) and von Willebrand factor antigen (vWF: Ag) rose significantly but factor V coagulability in both cases showed no change after DDAVP administration. These findings suggested that DDAVP might have other hemostatic effects of unknown mechanism in addition to the rise of plasma VIII: C and v WF: Ag levels.

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