1987 Volume 33 Issue 5 Pages 883-886
Cefotetan (CTT, YM 09330) is a cefamycin-type antibiotic with an expanded spectrum and potent activity against gram-negative bacteria including β-lactamase producing registant strain.
Cefotetan was administered intravenously for 1 hour at a dosage of 2.0g. The concentration of Cefotetan in the serum, mandibula, maxilla and soft tissue was measured by the agar-well method 12 hours after administering. Concentrations of Cefotetan in the tissues was highest in the soft tissue, followed by maxilla, and mandibula. Concentrations of gram-negative bacteria, with the exception of Ps. aeruginosa, were found to exceed MIC.
