Abstract
Tumor infiltrating lymphocytes (TIL) interact most closely with tumor cells and accurately reflect the tumor host relationship. Many reports have indicated that grade of TIL is concerned with clinical prognoses. On other hand, it is suggested that TIL are immunosuppressed and unable to provide antitumor activity.
In this study, we have attemptted preoperative intratumoral injections of OK-432 in oral cancer patients to reverse immune paralysis and induce antitumor activity. OK-432 is used widely as biological response modifiers in Japan. Analysis of TIL is performed by indirect immunohistologic technique with monoclonal antibody. It is suggested that OK-432 injection auguments the grade of TIL, in which Leu 3a+ cell, Leu 11a+ cell and LeuM1+ cell are significantry expanded and but Leu2a+ cell are not.
