Clinical evaluation of non-steroidal analgesic (Loxoprofen sodium, Loxonin^®) on the pain control after minor oral surgery

Abstract

Loxonin^® is one of the non-steroidal anti-inflammatory analgesics of the phenylpropionic acid group. It is known that its side effects on digestive organs are less than those of other analgesics because of “prodrug” A clinical evaluation of Loxonin^® on pain control
after minor oral surgery is here reported in regard to time course of effectiveness, side effects, its availability and related points reflect, c1 in pain control.
The number of test cases was 233 comprising 178 cases with single dose (120mg) only at pain onset and 55 cases with 3-divided doses (total 180mg). Of them, 23 cases were omitted because of no Loxonin^® without postcperative pains.
The benefit of the pain control method in the former cases reached 94.4% and the latter showed 96. 0%. The final availability was certainly more than 90% regardless of surgical treatments and inflammation degree before operation.
From the results, it turned out Loxonin^® was safe in the clinical use and highly effective in the pain control following minor oral surgery.