Abstract
Investigation to elucidate the histochemical characteristics of adenolymphoma using normal salivary gland tissue as control, was carried out in immunohistochemical and mucushistochemical technique and the following findings were obtained: Localization of IgA, LF and SC in normal salivary gland tissue, siuggesting the defence of acinus unit, was the pertinent finding for the tissue defence mechanism which supported the presence of SC-transport mechanism and local immune system. Localization of Keratin in tumor tissue, suggesting the characteristic picture of densely staining epithelial basal cell skin to excretory duct, is the finding strongly implicating the execretory duct epithelial origin. The fall in positive rate associated with tumorigenesis of LZ implicated involvement of LZ in tumorigenesis. Acid mucus is dominant in productive mucus in normal salivary gland tissue and sialomucin is dominent in tumor tissue. Though the presence of glycosaminoglycan was confirmed by performing enzyme digestion method in normal salivary gland tissues, the evidence of glycosaminoglycan was not observed and imvolvement of myo-epithelial cell in tumorigenesis was negatively supported. In double stain of each antibody and mucus, the tendency toward dissociation was observed in all antibodies. Its when the cell with mucus producting potential was considered as the cell relatively well-differentiated in terms of function, the possibility, that CEA, SC, IgA, K, LF, LZ were localized in the cells relatively poorly differentiated, was implicated. The localization of CEA in particular was suggested to be the possible index of cell dedifferentiation toward fetal tissue.
