1990 Volume 36 Issue 5 Pages 1320-1326
Twenty cases (4.3%) of multiple primary malignant tumors, including 3 cases of oral multicentric carcinoma, were found among 463 patients with malignant tumor of head and neck region at the our department, from September, 1978 through August, 1989. Ten were male and ten were female. Their mean age was 67.7±11.5 years with a range 34 to 82 years. Synchronous (within 1 year) tumor were 8 cases and metachronous were 12. The average interval between the first and second tumors was 4.0 years with a range of from 6 months to 14 years.
There was a wide variety of other tumors distributed as follows: pharynx (3), bladder (2), and parotid region, thyroid, bronchus, breast, esophagus, stomach, uterine cervix, and skin, each. One of this group, forty percent (8/20 cases, including oral multicentric carcinoma) were combined cancers of digestive system.
Three cases of radiation induced cancer were found.
