Abstract
Sixteen cases of adenocarcinoma arised from salivary glands were investigated in terms of immunohistochemical detections of lysozyme, secretory component, lactoferrin, keratin (total keratin, KL-1, PKK1) and S-100. The following results were obtained:
4 of 16 adenocarcinoma were positive for lysozyme, and lysozyme staining existed in well and moderately differentiated carcinomas. 7 of these adenocarcinomas showed a positive staining for secretory component, of which 1 had well, 5 moderate and 2 poor differentiated types. Localization of lysozyme and secretory component was frequently detected in the relatively well differentiated tumors. The combined findings of these two substances were considered to be the universal marker for the functional differentiation of adenocarcinoma.
Staining reaction for lysozyme, secretory component and lactoferrin was observed in the tumors 25%, 44% and 38% respectively. Immunohistochemical staining for these materials were mainly localized in the interlated ducts but lacked in excretory ducts in the normal salivary gland.
Keratin is a marker for the epithelial cells and tumors. All the adenocarcinomas were positive for total keratin and KL1, and 4 of these tumors-showed for reduced PKK1 staining with irregular distribution.
S-100 staining appeared in serous acinus cells nerves and skeletal muscles, but rnyoepithelial cells were devoid of S-100 reaction. It is suggested that adenocarcinoma in salivary gland origin did not originate front the terminal secretory epithelium.
