Relationship between the expression of E-cadherin and the mode of invasion in human primary oral cancer

Toshio SAKAKI; Masahiro WATO; Akio TANAKA; Ryuichi KAJI; Shigeru UENO; Kenji KAKUDO; Kozo MUSHIMOTO; Rikiya SHIRASU

doi:10.5794/jjoms.39.639

Toshio SAKAKI, Masahiro WATO, Akio TANAKA, Ryuichi KAJI, Shigeru UENO, Kenji KAKUDO, Kozo MUSHIMOTO, Rikiya SHIRASU

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Keywords: E-cadherin, oral squamous cell carcinoma, immunohistochemistry, invasiveness

JOURNAL FREE ACCESS

1993 Volume 39 Issue 6 Pages 639-644

DOI https://doi.org/10.5794/jjoms.39.639

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Abstract

We carried out immunohistochemical investigations on the relationship between the expression of E-cadherin and the clinical stage and mode of invasion of human primary oral cancers (squamous cell carcinomas).
We found that cancers having a grade 4 mode of invasion displayed a reduced type of E-cadherin expression by the classification of Shiozaki et al.
This suggests that decreased expression of E-cadherin is closely related to the high invasiveness of cancer cells.

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