Abstract
The effects of two different neo-adjuvant chemo- and radio-therapies against squamous cell carcinomas of the head and neck were compared histologically.
Group A consisted of 15 patients who received intra-arterial cisplatin (20 mg/m 2) on day 1 and 8, and intrarectal tegafur (1500 mg/day) from day 1 through 14, and irradiation of 2 Gy from day 1 through 5 and from day 8 through
Group B consisted of 14 patients, who received intra-arterial carboplatin (100 mg/m 2) on day 1 and 8, and intrarectal tegafur (1500 mg /day) from day 1 through 14, and irradiation of 2 Gy from day 1 through 5 and from day 8 through 12.
There was no difference between the groups in sex, age, T- and Stage-classification, and tumor cell differentiation.
Therapeutic effects were evaluated according to Oboshi's classification on the basis of resected tumor tissues. A grade of II B or more was judged as respondent, and a grade of less than Grade II A as nonrespondent. Seven out of 15 patients (46.7%) in group A and 8 out of 14 patients (57.1%) in Group B were judged as respondent. There was no significant difference in the respondent rate between the two groups. Mucositis occurred frequently, but surgery was not delayed in any patient.
