Abstract
Granular cell tumor is a rare benign tumor arising in various soft tissues of the body. Its pathogenesis is not clearly understood.
We report our experience with a 23-year-old woman, with a granular cell tumor arising in the margin of the tongue.
A mass arising in the left margin of the tongue was resected along with the peripheral soft tissue under local anesthesia. Recurrence was not found 3 months after resection. The microscopic pathological diagnosis was granular cell tumor.
Recent reports provide compelling evidence for the neurogenic hypothesis of granular cell tumors. The neurogenic hypothesis was also supported by our case because the granules in the granular cells were positively stained by the PAS reaction. In addition, immunohistochemical studies showed a positive reaction with the antibody against S-100 protein.
Six-patients (20-59 years old; mean age, 33.4 years old; 3 men, 3 women) have been given a diagnosis of “granular cell tumor” at our clinic during the past 20 years. All of these cases of granular cell tumor were found in the tongue.
