Abstract
Wegener's granulomatosis (WG) is a systemic disease Characterized by necrotizing granulomatous inflammation of the respiratory tract, kidney, and other organs. The most common initial symptom of this disease is necrotizing granuloma in the nasal and paranasal cavity, and oral lesions are rare. Here we report a case of WG associated with oral lesions as one of the initial symptoms. The patient was a 39-year-old man who was referred to Fukuroi Municipal Hospital because of nasal pain, nasal obstruction, chest pain, pyrexia, gingival swelling, and ulcers of the tongue and soft palate. On the basis of clinical, laboratory, and histopathological findings, a diagnosis of WG was made, and the patient was treated with a combination regimen of chemotherapy regimen of chemotherapy consisting of prednisone and cyclophosphamide. The patient responded very well to the treatment, and symptoms disappeared within 4 weeks. He remains free of any oral or systemic signs and symptoms as of 11 months after the initiation of treatment.
