A case of submandibular schwannoma in a 5-year-old boy

Abstract

A submandibular schwannoma in a 5-year-old boy was examined immunohistochemically using MIB-1 antibody. Histopathologically, the tumor cell nuclei formed a palisading pattern, typical of an Antoni type A tumor. MIB-1 positive cells were found mainly at the tumor margin, and the value was 11.9%. The average MIB-1 positive cell rate in juvenile and adult cases was 5.8% and 3.1%, respectively, and this difference was not significant. Cases of schwannoma of the oral and maxillofacial region in Japanese children were also reviewed and discussed.